Exogenous tumor necrosis factor-alpha induces suppression of autoimmune arthritis

Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis

INTRODUCTION Our previous studies showed that arthritic Lewis (LEW) rats produced the highest levels of tumour necrosis factor (TNF)alpha in the recovery phase of adjuvant arthritis (AA), suggesting a correlation between high TNFalpha levels and reduced severity of arthritis. To further explore this correlation, we compared the TNFalpha secretion profile of the AA-resistant Wistar Kyoto (WKY) r...

Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis

Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...

Autoimmune Pitfalls of Anti-Tumor Necrosis Factor-Alpha Therapy.

Tumor Necrosis Factor-Alpha at the Crossroad between Rheumatoid Arthritis and Autoimmune Cholangitis.

predominance of female patients [9]. RA is a chronic systemic inflammatory disease affecting approximately 0.5–1% of the general population, where genetics, environmental risk factors (such as smoking) and autoimmunity contribute to disease onset. RA is characterized by symmetric articular involvement, chronic synovitis and systemic inflammation with significant cardiovascular morbidity [10,11]...

Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target

In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference...